Burr1985bone

Bone remodeling in response to in vivo fatigue microdamage

Burr et al 1985

Notes

This is the dog ulna study.

Purpose

Determine thresholds for forces causing microdamage to bone in vivo and demonstrate that bone damage may be related to osteon activity/bone remodeling.

Methods

Experiment 1 (determine fatigue thresholds)
  • 11 adult stray dogs had strain gauges attached to their radius and underwent a 3 point bending test at 2Hz.
  • Applied forces similar to those experienced during walking, although the bending was different than normal.
  • Dogs separated into 5 groups of loading: control + 4 variations of force/number of cycles:
  • After loading, dogs were sacrificed and bones were removed and microscopy was performed on a sample.
    Experiment 2 (Observe bone remodeling)
  • 8 adult stray dogs went through the same proceude but only at 1500 microstrain for 10k cycles (equivalent to Group 5)
  • Dogs were sacrificed after 1, 2, or 4 days to allow for bone remodeling to begin, then used microscopy to analyze damage

    Results

    Experiment 1
  • 1500 microstrains for 10k cycles produced increases in microdamage compared to controls and other strain groups. This is like 11 miles of running for a dog (~1 or 2 days of activity)
    Experiment 2
  • Radii and Ulnae were grouped together to increase sample size
  • Found evidence of bone resorption at damage locations and an association between microcracks and repair sites.

    Discussion

    Evidence supports potential cause/effect relationship between accumulation of fatigue damage and bone remodeling in areas where the damage occurs. Low thresholds for fatigue damage suggest our bones may be remodeling all the time during typical daily activity.

Bones adapt to the load placed upon them: Bouvier and Hylander 1981 fed macaques one of two diets, consisting of either hard or soft food. They found greater bone remodelling in the monkeys who ate the hard diet. Hypothesized that increased remodelling was a product of high straings and/or increased number of load cycles (bites/chews).

Notable References

  1. Martin and Burr (Hypothetical mechanism for the stimulation of osteonal remodelling by fatigue damage)
  2. Frost 1960
  3. Frost 1966